His Highness Sheikh Mohammed bin Zayed Al Nahya is married to Sheikha Salama bint Hamdan bin Mohammed Al Nahyan. They were married in 1981 and have four sons and five daughters and they are :
Sheikh Khalid bin Mohammedbin Zayed Al Nahyan Sheikh Theyab bin Mohammed bin Zayed Al Nahyan Sheikh Hamdan bin Mohammed bin Zayed Al Nahyan Sheikh Zayed bin Mohammed bin Zayed Al Nahyan Sheikha Maryam bint Mohammed bin Zayed Al Nahyan Sheikha Shama bint Mohammed bin Zayed Al Nahyan Sheikha Shamsa bint Mohammed bin Zayed Al Nahyan Sheikha Fatima bint Mohammed bin Zayed Al Nahyan Sheikha Hesa bint Mohammed bin Zayed Al Nahyan
Sheikh Mohammed bin Zayed Al Nahyan cares about the enviroment and near extinction animals and plants. Also, he has established many organizations and funds to support the environment such as, the Mohamed bin Zayed Species Conservation Fund and Masdar City on 2006 (the alternative energy project in Abu Dhabi).
Moreover, His Highness Sheikh Mohammed bin Zayed is interested in falconry sport and he is committed to the protection of falcons, Oryx and the houbara from Arabian Peninsula.